Aacrjournals - clincancerres.aacrjournals.org - Clinical Cancer Research current issue
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Phospho-cMET and Multiple Myeloma Progression 14 Aug 2013 | 09:06 am
Purpose: The aim of the study was to verify the hypothesis that the cMet oncogene is implicated in chemio- and novel drug resistance in multiple myeloma. Experimental Design: We have evaluated the ex...
Dual BRAF Inhibition and Hdm2 Antagonism in Melanoma 14 Aug 2013 | 09:06 am
Purpose: For patients with advanced melanoma, primary and secondary resistance to selective BRAF inhibition remains one of the most critically compelling challenges. One rationale argues that novel bi...
Anti-VEGF-Mediated Mesenchymal Transition 14 Aug 2013 | 09:06 am
Purpose: Antiangiogenic therapy reduces vascular permeability and delays progression but may ultimately promote an aggressive treatment-resistant phenotype. The aim of the present study was to identif...
{beta}-ManCer does not Induce Anergy 14 Aug 2013 | 09:06 am
Purpose: Most studies characterizing antitumor properties of invariant natural killer T (iNKT) cells have used the agonist, α-galactosylceramide (α-GalCer). However, α-GalCer induces strong, long-last...
Chk1 Inhibitor MK8776 with Chemoradiation in Pancreatic Cancer 14 Aug 2013 | 09:06 am
Purpose: The combination of radiation with chemotherapy is the most effective therapy for unresectable pancreatic cancer. To improve upon this regimen, we combined the selective Checkpoint kinase 1 (C...
Radiosensitization by PP2A Inhibition 14 Aug 2013 | 09:06 am
Purpose: To identify targets whose inhibition may enhance the efficacy of chemoradiation in pancreatic cancer and thus improve survival, we conducted an siRNA library screen in pancreatic cancer cells...
A Humanized Antibody Targeting CXCL12 14 Aug 2013 | 09:06 am
Purpose: Our goal was to develop a potent humanized antibody against mouse/human CXCL12. This report summarized its in vitro and in vivo activities. Experimental Design: Cell surface binding and cell...
Memantine Protects against Methotrexate-Induced Memory Deficits 14 Aug 2013 | 09:06 am
Purpose: To test whether memantine can prevent methotrexate-induced cognitive deficits in a preclinical model. Experimental Design: After noting that methotrexate exposure induces prolonged elevation...
ALDH3 Activation Reduces Radiotherapy-Induced Xerostomia 14 Aug 2013 | 09:06 am
Purpose: To determine the effect of Alda-89 (an ALDH3 activitor) on (i) the function of irradiated (radiotherapy) submandibular gland (SMG) in mice, (ii) its toxicity profile, and (iii) its effect on ...
Nimbolide Inhibits Colorectal Cancer Growth 14 Aug 2013 | 09:06 am
Purpose: Extensive research over the past decade has revealed that the proinflammatory microenvironment plays a critical role in the development of colorectal cancer. Whether nimbolide, a limonoid tri...
