Selected Articles from This Issue 16 Aug 2013 | 09:06 am

JAK2 Regulation and Activation Model 16 Aug 2013 | 09:06 am

Janus kinase 2 (JAK2) is a protein tyrosine kinase central to a multitude of cellular processes. Here, a novel model of JAK2 regulation and activation is proposed. In the JAK2 dimer, instead of being ...

Mutations in MDS and AML 16 Aug 2013 | 09:06 am

Over the past few years, large-scale genomic studies of patients with myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) have unveiled recurrent somatic mutations in genes involved in...

ARF Regulates the Stability of p16 Protein 16 Aug 2013 | 09:06 am

The cell-cycle regulatory gene INK4A-ARF (CDKN2A) has two alternative transcripts that produce entirely different proteins, namely p14ARF and p16, which have complementary functions as regulators of p...

FoxM1 and hsa-miR-370 in H. pylori-Induced Gastric Carcinogenesis 16 Aug 2013 | 09:06 am

Helicobacter pylori (H. pylori) infections are strongly implicated in human gastric mucosa–associated diseases. Forkhead box M1 (FoxM1), a key positive regulator of cell proliferation, is overexpresse...

Suppression of PP4C Triggers Mitotic Slippage and Apoptosis 16 Aug 2013 | 09:06 am

Fostriecin is a natural product purified from Sterptomyces extracts with antitumor activity sufficient to warrant human clinical trials. Unfortunately, difficulties associated with supply and stable d...

Novel Tubulin-Targeted Therapeutics 16 Aug 2013 | 09:06 am

We have developed a novel class (2-amino-4-phenyl-4H-chromene-3-carboxylate) of inhibitors of tubulin assembly by modifying HA14-1, which is a Bcl-2 inhibitor discovered by our group. Three of these c...

TROY Signaling in Glioblastoma Survival 16 Aug 2013 | 09:06 am

Of the features that characterize glioblastoma, arguably none is more clinically relevant than the propensity of malignant glioma cells to aggressively invade into the surrounding normal brain tissue....

FOXM1 Interacts with Sp1 to Regulate COX-2 16 Aug 2013 | 09:06 am

Cyclooxygenase-2 (COX-2) is linked to poor prognosis in patients with malignant gliomas. Amplification/overexpression of epidermal growth factor receptor (EGFR) is commonly seen in these tumors. EGFR ...

Misregulation of IRES-Dependent Translation of Aurora A mRNA 16 Aug 2013 | 09:06 am

Overexpression of the oncoprotein Aurora A kinase occurs in multiple types of cancer, often early during cell transformation. To identify the mechanism(s) contributing to enhanced Aurora A protein exp...