Src-Mediated TKI Resistance in Smoking-Related Lung Cancer 9 Aug 2013 | 09:06 am

The EGF receptor (EGFR) is a proto-oncogene commonly dysregulated in several cancers including non–small cell lung carcinoma (NSCLC) and, thus, is targeted for treatment using tyrosine kinase inhibito...

AML Fusion Proteins Enhance DNA Damage by HDAC Inhibitors 9 Aug 2013 | 09:06 am

Histone deacetylase inhibitors (HDI) show activity in a broad range of hematologic and solid malignancies, yet the percentage of patients in any given malignancy who experience a meaningful clinical r...

Metformin Inhibits Melanoma Invasion 9 Aug 2013 | 09:06 am

Metformin was reported to inhibit the proliferation of many cancer cells, including melanoma cells. In this report, we investigated the effect of metformin on melanoma invasion and metastasis developm...

p14ARF Regulation in Gefitinib-Treated NSCLC 9 Aug 2013 | 09:06 am

Activation of the epidermal growth factor receptor (EGFR) has been observed in many malignant tumors and its constitutive signal transduction facilitates the proliferation of tumors. EGFR-tyrosine kin...

NF-{kappa}B2/p52 Induces Resistance to Enzalutamide 9 Aug 2013 | 09:06 am

Resistance of prostate cancer cells to the next-generation antiandrogen enzalutamide may be mediated by a multitude of survival signaling pathways. In this study, we tested whether increased expressio...

C/EBP Regulation of CPO for Differentiation-Enhanced PDT 9 Aug 2013 | 09:06 am

The efficacy of photodynamic therapy (PDT) for epithelial cancers is increased when PDT is combined with calcitriol (Vit D), a form of differentiation therapy (DT). Here, we describe an underlying mec...

Transcriptional Targeting Strategy for Human HCC 9 Aug 2013 | 09:06 am

Gene regulation of many key cell-cycle players in S-, G2 phase, and mitosis results from transcriptional repression in their respective promoter regions during the G0 and G1 phases of cell cycle. With...

Targeting of AKT and mTOR in Basal-like Breast Cancer 9 Aug 2013 | 09:06 am

Basal-like breast cancer is an aggressive disease for which targeted therapies are lacking. Recent studies showed that basal-like breast cancer is frequently associated with an increased activity of t...

TLR4 Promotes Chemoresistance 9 Aug 2013 | 09:06 am

Overexpression of Toll-like receptor-4 (TLR4) in human tumors often correlates with chemoresistance and metastasis. We found that TLR4 is overexpressed in the majority of clinical breast cancer sample...

Correction: Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents 9 Aug 2013 | 09:06 am