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CD81 Controls Sustained T Cell Activation Signaling and Defines the Maturation Stages of Cognate Immunological Synapses [Articles] 23 Aug 2013 | 08:04 pm
In this study, we investigated the dynamics of the molecular interactions of tetraspanin CD81 in T lymphocytes, and we show that CD81 controls the organization of the immune synapse (IS) and T cell ac...
Parkin-Dependent Degradation of the F-Box Protein Fbw7{beta} Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1 [Articles... 23 Aug 2013 | 08:04 pm
Parkinson's disease (PD) is characterized by progressive loss of midbrain dopaminergic neurons resulting in motor dysfunction. While most PD is sporadic in nature, a significant subset can be linked t...
Correct Assembly of RNA Polymerase II Depends on the Foot Domain and Is Required for Multiple Steps of Transcription in Saccharomyces cerevisiae [Arti... 23 Aug 2013 | 08:04 pm
Recent papers have provided insight into the cytoplasmic assembly of RNA polymerase II (RNA pol II) and its transport to the nucleus. However, little is known about the mechanisms governing its nuclea...
Genome-Wide Analysis of Chromatin States Reveals Distinct Mechanisms of Sex-Dependent Gene Regulation in Male and Female Mouse Liver [Articles] 23 Aug 2013 | 08:04 pm
Chromatin state maps were developed to elucidate sex differences in chromatin structure and their impact on sex-differential chromatin accessibility and sex-biased gene expression in mouse liver. Gene...
Huntingtin-Interacting Protein 1 Phosphorylation by Receptor Tyrosine Kinases [Articles] 23 Aug 2013 | 08:04 pm
Huntingtin-interacting protein 1 (HIP1) binds inositol lipids, clathrin, actin, and receptor tyrosine kinases (RTKs). HIP1 is elevated in many tumors, and its expression is prognostic in prostate canc...
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination [Articles] 23 Aug 2013 | 08:04 pm
V(D)J recombination is initiated by the RAG endonuclease, which introduces DNA double-strand breaks (DSBs) at the border between two recombining gene segments, generating two hairpin-sealed coding end...
Mechanisms of Antisense Transcription Initiation from the 3' End of the GAL10 Coding Sequence In Vivo [Articles] 23 Aug 2013 | 08:04 pm
In spite of the important regulatory functions of antisense transcripts in gene expression, it remains unknown how antisense transcription is initiated. Recent studies implicated RNA polymerase II in ...
Interaction between 25S rRNA A Loop and Eukaryotic Translation Initiation Factor 5B Promotes Subunit Joining and Ensures Stringent AUG Selection [Arti... 23 Aug 2013 | 08:04 pm
In yeast, 25S rRNA makes up the major mass and shape of the 60S ribosomal subunit. During the last step of translation initiation, eukaryotic initiation factor 5B (eIF5B) promotes the 60S subunit join...
