Therapeutic Targeting of Autophagy in Disease: Biology and Pharmacology [Review Articles] 13 Aug 2013 | 07:29 pm

Autophagy, a process of self-digestion of the cytoplasm and organelles through which cellular components are recycled for reuse or energy production, is an evolutionarily conserved response to metabol...

Aryl Hydrocarbon Receptor Control of Adaptive Immunity [Review Articles] 1 Aug 2013 | 09:52 pm

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that belongs to the family of basic helix-loop-helix transcription factors. Although the AhR was initially recognized as ...

Recent Progress in Prostaglandin F2{alpha} Ethanolamide (Prostamide F2{alpha}) Research and Therapeutics [Review Articles] 26 Jul 2013 | 10:53 pm

Prostamide (prostaglandin ethanolamide) research emerged from two distinct lines of research: 1) the unique pharmacology of the antiglaucoma drug bimatoprost and 2) the discovery that endocannabinoid ...

Correction to "Exchange Protein Directly Activated by cAMP (epac): A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions" [Err... 1 Jul 2013 | 09:50 pm

The Pharmacology of Regenerative Medicine [Review Articles] 1 Jul 2013 | 09:50 pm

Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tiss...

Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs [Review Articles] 26 Jun 2013 | 11:41 pm

Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an important tool for rational drug development and drug use, where developed models characterize both the typical trends ...

The Prostanoid EP4 Receptor and Its Signaling Pathway [Review Articles] 17 Jun 2013 | 08:48 pm

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It belongs to the family of G protein–coupled receptors. It was originally identified, similar to the EP2 receptor as...

Transporters and Drug-Drug Interactions: Important Determinants of Drug Disposition and Effects [Review Articles] 17 May 2013 | 05:44 pm

Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety of drugs. They are localized in organs such as small intestine, liver, and kidney, which are critical for d...

International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligan... 17 May 2013 | 05:44 pm

In 2005, the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of the human gene sequences known ...

Pharmacogenetics and Cardiovascular Disease--Implications for Personalized Medicine [Review Articles] 17 May 2013 | 05:44 pm

The past decade has seen tremendous advances in our understanding of the genetic factors influencing response to a variety of drugs, including those targeted at treatment of cardiovascular diseases. I...