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Diminazene Attenuates Pulmonary Hypertension and Improves Angiogenic Progenitor Cell Functions in Experimental Models 15 Mar 2013 | 05:08 pm
Rationale: Studies have demonstrated that angiotensin-converting enzyme 2 (ACE2) plays a protective role against lung diseases, including pulmonary hypertension (PH). Recently, an antitrypanosomal dru...
Reestablishment of Recipient-associated Microbiota in the Lung Allograft Is Linked to Reduced Risk of Bronchiolitis Obliterans Syndrome 15 Mar 2013 | 05:08 pm
Rationale: Bronchiolitis obliterans syndrome (BOS) is the primary limiting factor for long-term survival after lung transplantation, and has previously been associated with microbial infections. Obje...
{beta}-Catenin in the Alveolar Epithelium Protects from Lung Fibrosis after Intratracheal Bleomycin 15 Mar 2013 | 05:08 pm
Rationale: Alveolar epithelial cells (AECs) play central roles in the response to lung injury and the pathogenesis of pulmonary fibrosis. Objectives: We aimed to determine the role of β-catenin in al...
A Th17- and Th2-skewed Cytokine Profile in Cystic Fibrosis Lungs Represents a Potential Risk Factor for Pseudomonas aeruginosa Infection 15 Mar 2013 | 05:08 pm
Rationale: Cystic fibrosis (CF) is characterized by progressive pulmonary inflammation that is infection-triggered. Pseudomonas aeruginosa represents a risk factor for deterioration of lung function a...
Th17/Treg Imbalance in Murine Cystic Fibrosis Is Linked to Indoleamine 2,3-Dioxygenase Deficiency but Corrected by Kynurenines 15 Mar 2013 | 05:08 pm
Rationale: Mutations in the cystic fibrosis (CF) transmembrane conductance regulator affect the innate epithelial immune function of the lung, resulting in exaggerated and ineffective airway inflammat...
Mortality by Level of Emphysema and Airway Wall Thickness 15 Mar 2013 | 05:08 pm
Rationale: There is limited knowledge of the prognostic value of quantitative computed tomography (CT) measures of emphysema and airway wall thickness (AWT) on mortality. Objectives: To examine 8-yea...
Quantifying Health Services Use for Chronic Obstructive Pulmonary Disease 15 Mar 2013 | 05:08 pm
Rationale: Chronic obstructive pulmonary disease (COPD), a common manageable condition, is a leading cause of death. A better understanding of its impact on health-care systems would inform strategies...
Pathogenic Bacteria Colonizing the Airways in Asymptomatic Neonates Stimulates Topical Inflammatory Mediator Release 15 Mar 2013 | 05:08 pm
Rationale: Bacterial colonization of neonatal airways with the pathogenic bacterial species, Moraxella catarrhalis, Streptococcus pneumoniae, and Haemophilus influenzae, is associated with later devel...
ADCYAP1R1 and Asthma in Puerto Rican Children 15 Mar 2013 | 05:08 pm
Rationale: Epigenetic and/or genetic variation in the gene encoding the receptor for adenylate-cyclase activating polypeptide 1 (ADCYAP1R1) has been linked to post-traumatic stress disorder in adults ...
Exercise-induced Pulmonary Hypertension: Physiological Basis and Methodological Concerns 15 Mar 2013 | 05:08 pm
Exercise stresses the pulmonary circulation through increases in cardiac output ( $$\stackrel{.}{\hbox{ Q }}$$ ) and left atrial pressure. Invasive as well as noninvasive studies in healthy volunteers...
