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PRINCIPLES FOR DESIGNING IDEAL PROTEIN STRUCTURES 28 Nov 2012 | 06:23 am
Koga, N., Tasumi-Koga R., et al., Nature. 491(7423), 222-227. (2012) We describe an approach to designing ideal protein structures stabilized by completely consistent local and non-local interactions...
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy 1 Jun 2012 | 07:30 am
King, N.P., Sheffler, W., et al. Science. 336(6085), 1171-1174. (2012) We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Prote...
Atomic model of the type III secretion system needle 1 Jun 2012 | 07:20 am
Loquet, A., Sgourakis N. G., et al. Nature (2012) The ability of Gram-negative bacteria, such as the agents of plague, dysentery and typhoid fever to infect host cells is dependent on a syringe-like...
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis 29 Mar 2012 | 11:33 am
Khare, S. D., Kipnis Y., et al. Nature chemical biology (2012) The ability to redesign enzymes to catalyze noncognate chemical transformations would have wide-ranging applications. We developed a co...
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing 29 Mar 2012 | 07:35 am
Whitehead, T. A., Chevalier A. et al. Nature biotechnology (2012) We show that comprehensive sequence-function maps obtained by deep sequencing can be used to reprogram interaction specificity and to...
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players 20 Mar 2012 | 01:37 pm
Eiben, C. B., Siegel J. B., Bale J. B. et al. Nature biotechnology. 30(2), 190-2. (2012) Computational enzyme design holds promise for the production of renewable fuels, drugs and chemicals. De novo...
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant 13 Mar 2012 | 05:32 pm
Bouvignies, G., Vallurupalli P., et al. Nature. 477(7362), 111-4. (2011) Proteins are inherently plastic molecules, whose function often critically depends on excursions between different molecula...
Algorithm discovery by protein folding game players 13 Mar 2012 | 05:32 pm
Khatib, F., Cooper S., Tyka M. D., Xu K., Makedon I., Popovic Z., et al. Proc Natl Acad Sci USA (2011) To determine whether high performing Foldit player strategies could be collectively codified, we...
Community computing allows everyone to get involved from home 14 Feb 2012 | 09:01 am
Foldit is a revolutionary new computer game enabling you to contribute to important scientific research. Join this free online game and help us predict the folds of unsolved proteins as well as des...
Crystal structure of a monomeric retroviral protease solved by protein folding game players 21 Sep 2011 | 05:56 pm
Khatib, F., DiMaio F., Contenders Group F., Void Crushers Group F. et al. Nature Structural & Molecular Biology (2011) Following the failure of a wide range of attempts to solve the crystal structure...
