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Highlights from this issue 9 Aug 2013 | 06:02 pm
The inhaler from UNCLE Times change, but does the way we deliver medications to the airways? Those of us old enough to remember episodes of ‘The Man from UNCLE’ will recall computers filling a whole ...
Whose risk is it anyway? 9 Aug 2013 | 06:02 pm
Powell et al 1 have proposed the importance of 90-day mortality after lung cancer surgery, and have generated a predictive score using predominantly objective information. There are obvious advantages...
SKUP3: a major step forward in sleep surgery research 9 Aug 2013 | 06:02 pm
Positive airway pressure is recognised as the first-line treatment for moderate to severe obstructive sleep apnoea (OSA) in many countries because of its low risks and high efficacy. Unfortunately, be...
Eight o'clock ROCK! 9 Aug 2013 | 06:02 pm
The latest Thorax impact factor has climbed to a record 8.376, which is great for the journal, and owes a huge amount to very many people. We'd like to thank the Deputy and Associate Editors, the bril...
Expression of vascular remodelling markers in relation to bradykinin receptors in asthma and COPD 9 Aug 2013 | 06:02 pm
Background Vascular remodelling plays a central role in asthma and chronic obstructive pulmonary disease (COPD). Bradykinin (BK) is a vasoactive proinflammatory peptide mediating acute responses in a...
Inhaled, dual release liposomal ciprofloxacin in non-cystic fibrosis bronchiectasis (ORBIT-2): a randomised, double-blind, placebo-controlled trial 9 Aug 2013 | 06:02 pm
Background The delivery of antipseudomonal antibiotics by inhalation to Pseudomonas aeruginosa-infected subjects with non-cystic fibrosis (CF) bronchiectasis is a logical extension of treatment strat...
Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection 9 Aug 2013 | 06:02 pm
Rationale Arikace is a liposomal amikacin preparation for aerosol delivery with potent Pseudomonas aeruginosa killing and prolonged lung deposition. Objectives To examine the safety and efficacy of...
Reduced pH in the airways alters bacterial killing in CFTR-/- porcine lungs 9 Aug 2013 | 06:02 pm
Molecular defects in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene are well understood. Despite this, how defects in the CFTR lead to CF is not clear. This paper addresses t...
Early mortality after surgical resection for lung cancer: an analysis of the English National Lung cancer audit 9 Aug 2013 | 06:02 pm
Introduction For appropriately staged non-small cell lung cancer (NSCLC) surgical resection can dramatically improve survival, but some may not be offered this treatment because of concerns about per...
Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose 9 Aug 2013 | 06:02 pm
Background Diabetes is a risk factor for respiratory infection, and hyperglycaemia is associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus infection. Objectiv...
