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In Vivo Reversible Regulation of Dendritic Patterning by Afferent Input in Bipolar Auditory Neurons 16 Aug 2012 | 12:01 am
Afferent input regulates neuronal dendritic patterning locally and globally through distinct mechanisms. To begin to understand these mechanisms, we differentially manipulate afferent input in vivo an...
Alteration in Neonatal Nutrition Causes Perturbations in Hypothalamic Neural Circuits Controlling Reproductive Function 16 Aug 2012 | 12:01 am
It is increasingly accepted that alterations of the early life environment may have lasting impacts on physiological functions. In particular, epidemiological and animal studies have indicated that ch...
A Retinal Ganglion Cell That Can Signal Irradiance Continuously for 10 Hours 16 Aug 2012 | 12:01 am
A recently discovered type of mammalian retinal ganglion cell encodes environmental light intensity and mediates non-image-forming visual behaviors, such as the pupillary reflex and circadian photoent...
Effect of CB1 Receptor Blockade on Food-Reinforced Responding and Associated Nucleus Accumbens Neuronal Activity in Rats 16 Aug 2012 | 12:01 am
Studies have shown that disruption of cannabinoid receptor signaling reduces operant responses for rewards; yet it is unknown whether changes in neural activity at dopamine terminal regions such as th...
Elimination of GRK2 from Cholinergic Neurons Reduces Behavioral Sensitivity to Muscarinic Receptor Activation 16 Aug 2012 | 12:01 am
Although G-protein-coupled receptor kinase 2 (GRK2) is the most widely studied member of a family of kinases that has been shown to exert powerful influences on a variety of G-protein-coupled receptor...
Effective Connectivity of the Human Cerebellum during Visual Attention 16 Aug 2012 | 12:01 am
Insights from both lesion and neuroimaging studies increasingly substantiate the view that the human cerebellum not only serves motor control but also supports various cognitive processes. Higher cogn...
Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission 16 Aug 2012 | 12:01 am
The mammalian target of rapamycin (mTOR) signaling pathway in neurons integrates a variety of extracellular signals to produce appropriate translational responses. mTOR signaling is hyperactive in neu...
Topography of Native SK Channels Revealed by Force Nanoscopy in Living Neurons 16 Aug 2012 | 12:01 am
The spatial distribution of ion channels is an important determinant of neuronal excitability. However, there are currently no quantitative techniques to map endogenous ion channels with single-channe...
Amygdalar Stimulation Produces Alterations on Firing Properties of Hippocampal Place Cells 16 Aug 2012 | 12:01 am
Stress is a biologically ubiquitous factor that, when perceived uncontrollable by humans and animals, can have lingering adverse effects on brain and cognitive functions. We have previously reported t...
Alternative Splicing of the TRPC3 Ion Channel Calmodulin/IP3 Receptor-Binding Domain in the Hindbrain Enhances Cation Flux 16 Aug 2012 | 12:01 am
Canonical transient receptor potential (TRPC3) nonselective cation channels are effectors of G-protein-coupled receptors (GPCRs), activated via phospholipase C–diacylglycerol signaling. In cerebellar ...