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Competition between virus-derived and endogenous small RNAs regulates gene expression in Caenorhabditis elegans [RESEARCH] 1 Aug 2013 | 07:00 pm
Positive-strand RNA viruses encompass more than one-third of known virus genera and include many medically and agriculturally relevant human, animal, and plant pathogens. The nematode Caenorhabditis e...
Extensive chromosomal reshuffling drives evolution of virulence in an asexual pathogen [RESEARCH] 1 Aug 2013 | 07:00 pm
Sexual recombination drives genetic diversity in eukaryotic genomes and fosters adaptation to novel environmental challenges. Although strictly asexual microorganisms are often considered as evolution...
Proteome-wide discovery of mislocated proteins in cancer [METHOD] 1 Aug 2013 | 07:00 pm
Several studies have sought systematically to identify protein subcellular locations, but an even larger task is to map which of these proteins conditionally relocates in disease (the mislocalizome). ...
Inferring chromatin-bound protein complexes from genome-wide binding assays [METHOD] 1 Aug 2013 | 07:00 pm
Genome-wide binding assays can determine where individual transcription factors bind in the genome. However, these factors rarely bind chromatin alone, but instead frequently bind to cis-regulatory el...
Comprehensive prediction in 78 human cell lines reveals rigidity and compactness of transcription factor dimers [METHOD] 1 Aug 2013 | 07:00 pm
The binding of transcription factors (TFs) to their specific motifs in genomic regulatory regions is commonly studied in isolation. However, in order to elucidate the mechanisms of transcriptional reg...
Mapping functional transcription factor networks from gene expression data [METHOD] 1 Aug 2013 | 07:00 pm
A critical step in understanding how a genome functions is determining which transcription factors (TFs) regulate each gene. Accordingly, extensive effort has been devoted to mapping TF networks. In S...
The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains [RESOURCES] 1 Aug 2013 | 07:00 pm
Commonly used classical inbred mouse strains have mosaic genomes with sequences from different subspecific origins. Their genomes are derived predominantly from the Western European subspecies Mus mus...
The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures [RESOURCES] 1 Aug 2013 | 07:00 pm
RNA polymerase transcription initiation sites are largely unknown in Caenorhabditis elegans. The initial 5' end of most protein-coding transcripts is removed by trans-splicing, and noncoding initiatio...
The transcription start site landscape of C. elegans [RESOURCES] 1 Aug 2013 | 07:00 pm
More than half of Caenorhabditis elegans pre-mRNAs lose their original 5' ends in a process termed "trans-splicing" in which the RNA extending from the transcription start site (TSS) to the site of tr...
