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Mitotane levels predict the outcome of patients with adrenocortical carcinoma treated adjuvantly following radical resection 29 Jul 2013 | 06:51 pm
Context Mitotane plasma concentrations ≥14 mg/l have been shown to predict tumor response and better survival in patients with advanced adrenocortical carcinoma (ACC). A correlation between mitotane ...
The clinical spectrum of RET proto-oncogene mutations in codon 790 29 Jul 2013 | 06:51 pm
Objective Due to a strong genotype–phenotype correlation, the timing of prophylactic thyroidectomy in rearranged during transfection (RET) gene mutation carriers is usually dictated by genetic analys...
A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome 29 Jul 2013 | 06:51 pm
Objective Individual sensitivity to recombinant human GH (r-hGH) is variable. Identification of genetic factors contributing to this variability has potential use for individualization of treatment. ...
Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes 29 Jul 2013 | 06:51 pm
Objective The aim of this study was to investigate the association of risk variants for type 2 diabetes (T2D) and hyperglycemia with gestational diabetes (GDM). Design and methods Five hundred and ...
Transforming growth factor {beta}1 is not a reliable biomarker for valvular fibrosis but could be a potential serum marker for invasiveness of prolact... 29 Jul 2013 | 06:51 pm
Background Transforming growth factor β1 (TGFβ1) signaling pathway is crucial for both human fibrogenesis and tumorigenesis. Objective This study aimed to investigate the usefulness of TGFβ1 and ma...
PAX8 is expressed in anaplastic thyroid carcinoma diagnosed by fine-needle aspiration: a study of three cases with histological correlates 29 Jul 2013 | 06:51 pm
Objective It is difficult to diagnose anaplastic thyroid carcinoma (ATC) in a fine-needle aspiration (FNA) sample because, given the loss of morphological and immunophenotypical follicular thyroid fe...
Pregnancy outcomes in women with severe hypothyroidism 29 Jul 2013 | 06:51 pm
Objective Hypothyroidism during pregnancy has been associated with adverse obstetrical outcomes. Most studies have focused on subjects with a mild or subclinical disorder. The aims of the present stu...
Oral low-dose testosterone administration induces whole-body protein anabolism in postmenopausal women: a novel liver-targeted therapy 29 Jul 2013 | 06:51 pm
Objective In hypopituitary men, oral delivery of unesterified testosterone in doses that result in a solely hepatic androgen effect enhances protein anabolism during GH treatment. In this study, we a...
Nocturnal intermittent hypoxia as an associated risk factor for microalbuminuria in Japanese patients with type 2 diabetes mellitus 20 Jul 2013 | 02:41 pm
Objective We estimated the prevalence of nocturnal intermittent hypoxia, a surrogate marker of obstructive sleep apnoea, among type 2 diabetes mellitus (T2DM) patients and examined the association be...
Ki-67 is a predictor of acromegaly control with octreotide LAR independent of SSTR2 status and relates to cytokeratin pattern 15 Jul 2013 | 08:42 pm
Introduction Only one study has evaluated Ki-67 as a predictor of the response to somatostatin analog therapy in acromegaly; however, other predictors like somatostatin receptor type 2 (SSTR2) and cy...
