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Maternal-fetal transfer of selenium in the mouse [Research Communications] 1 Aug 2013 | 12:01 pm
Selenoprotein P (Sepp1) is taken up by receptor-mediated endocytosis for its selenium. The other extracellular selenoprotein, glutathione peroxidase-3 (Gpx3), has not been shown to transport selenium....
Vascular endothelial growth factor is important for brown adipose tissue development and maintenance [Research Communications] 1 Aug 2013 | 12:01 pm
Vascular endothelial growth factor (VEGF) is critical for angiogenesis, but also has pleiotropic effects on several nonvascular cells. Our aim was to investigate the role of VEGF in brown adipose tiss...
A novel peptide carrier for efficient targeting of antigens and nucleic acids to dendritic cells [Research Communications] 1 Aug 2013 | 12:01 pm
Dendritic cells (DCs) initiate host immune responses by presenting captured antigens to naive T cells. Hence, DC-binding peptides may be used for antigen targeting to boost naive and memory immune res...
Sphingomyelin regulates the transbilayer movement of diacylglycerol in the plasma membrane of Madin-Darby canine kidney cells [Research Communications... 1 Aug 2013 | 12:01 pm
Diacylglycerol (DAG) is a key component in lipid metabolism and signaling. Previous model membrane studies using DAG analogs suggest their rapid membrane transbilayer movement. However, little is know...
Multiple coagulation factor deficiency protein 2 contains the ability to support stem cell self-renewal [Research Communications] 1 Aug 2013 | 12:01 pm
Defects in multiple coagulation factor deficiency protein 2 (MCFD2) are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D). MCFD2 was also suggested to play an important role as an...
Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia [Research Communications] 1 Aug 2013 | 12:01 pm
Leukotriene B4 (LTB4) has been implicated in the pathogenesis of allergic diseases. BLT2, a low-affinity LTB4 receptor, is activated by LTB4 and 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT)...
Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation [Research Communications] 1 Aug 2013 | 12:01 pm
Peroxiredoxin 2 (Prx2) is an abundant thiol protein in erythrocytes. It is oxidized readily on exposure to hydrogen peroxide (H2O2) and provides antioxidant protection by cycling between its reduced a...
Maternal folate depletion and high-fat feeding from weaning affects DNA methylation and DNA repair in brain of adult offspring [Research Communication... 1 Aug 2013 | 12:01 pm
The mechanisms through which environmental and dietary factors modulate DNA repair are still unclear but may include dysregulation of gene expression due to altered epigenetic markings. In a mouse mod...
The prevalence of loss of imprinting of H19 and IGF2 at birth [Research Communications] 1 Aug 2013 | 12:01 pm
Imprinted genes are monoallelically expressed according to the parent of origin and are critical for proper placental and embryonic development. Disruption of methylation patterns at imprinted loci re...
Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1 [Research Communications] 1 Aug 2013 | 12:01 pm
Interactions between the immune and skeletal systems in inflammatory bone diseases are well appreciated, but the underlying molecular mechanisms that coordinate the resolution phase of inflammation an...
