Genomebiology - genomebiology.com - Genome Biology - Latest Articles
General Information:
Latest News:
DNA methylation: an identity card for brain cells 27 Aug 2013 | 05:00 am
A recently published study has revealed the genome-wide dynamics of DNA methylation and hydroxymethylation patterns at single-base resolution in the human and mouse developing brain.
Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits 23 Aug 2013 | 05:00 am
WaRSwap is a randomization algorithm that for the first time provides a practical network motif discovery method for large multi-layer networks, for example those that include transcription factors, m...
Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization 23 Aug 2013 | 05:00 am
Background: Developmental programs are implemented by regulatory interactions between Transcription Factors (TFs) and their target genes, which remain poorly understood. While recent studies have focu...
BreakTrans: uncovering the genomic architecture of gene fusions 23 Aug 2013 | 05:00 am
Producing gene fusions through genomic structural rearrangements is a major mechanism for tumor evolution. Therefore, accurately detecting gene fusions and the originating rearrangements is of great i...
Learning the language of post-transcriptional gene regulation 23 Aug 2013 | 05:00 am
A large-scale RNA in vitro selection study systematically identified RNA recognition elements for 205 RNA-binding proteins belonging to families conserved in most eukaryotes.
Conquering computational challenges of omics data and post-ENCODE paradigms 23 Aug 2013 | 05:00 am
A report on the 21st Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) and 12th European Conference on Computational Biology (ECCB), held in Berlin, Germany, July 21-...
Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function 19 Aug 2013 | 05:00 am
Background: Interindividual differences in liver functions such as protein synthesis, lipid and carbohydrate metabolism and drug metabolism are influenced by epigenetic factors. The role of the epigen...
PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs 19 Aug 2013 | 05:00 am
The regulation of intragenic miRNAs by their own intronic promoters is one of the open problems of miRNA biogenesis. Here, we describe PROmiRNA, a new approach for miRNA promoter annotation based on a...
Astrogenomics: big data, old problems, old solutions? 13 Aug 2013 | 05:00 am
{no abstract}
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains 31 Jul 2013 | 05:00 am
Background: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. More recently large initiatives such as The In...
