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Effect of Nitric Oxide on Anterior Segment Physiology in Monkeys [Physiology and Pharmacology] 30 Jul 2013 | 06:14 pm
Purpose. To determine the effect of the nitric oxide donor, sodium nitroprusside (SNP), and the nitric oxide synthase (NOS) inhibitor, L-nitro-arginine-methylester (L-NAME), on IOP, mean arterial pre...
Complementation Test of Rpe65 Knockout and Tvrm148 [Biochemistry and Molecular Biology] 30 Jul 2013 | 06:14 pm
Purpose. A mouse mutation, tvrm148, was previously reported as resulting in retinal degeneration. Tvrm148 and Rpe65 map between markers D3Mit147 and D3Mit19 on a genetic map, but the physical map pla...
Postocclusive Reactive Hyperemia Occurs in the Rat Retinal Circulation but Not in the Choroid [Physiology and Pharmacology] 30 Jul 2013 | 06:14 pm
Purpose. We tested the hypothesis that retinal blood flow has a postocclusive reactive hyperemia response modulated by occlusion duration and metabolic activity, and that choroidal blood flow does no...
Replication and Meta-Analysis of Candidate Loci Identified Variation at RAB3GAP1 Associated With Keratoconus [Genetics] 30 Jul 2013 | 06:14 pm
Purpose. Keratoconus is a common complex corneal ectasia that can lead to severe visual impairment. Although a genetic component is well recognized, the genetic risk factors for keratoconus are yet t...
In Vivo Analysis of Aquaporin 0 Function in Zebrafish: Permeability Regulation Is Required for Lens Transparency [Lens] 30 Jul 2013 | 06:14 pm
Purpose. The zebrafish lens is well suited for studies of physiology and development due to its rapid formation in the embryo and genetic accessibility. Aquaporin 0 (AQP0), a lens-specific membrane p...
Effect of Instillation of Eyedrops for Dry Eye on Optical Quality [Cornea] 26 Jul 2013 | 09:45 pm
Purpose. To investigate the effects of viscosity and suspensibility of eyedrops for dry eye by evaluating an eyedrop with one of the solutions or no solution (0.3% sodium hyaluronate ophthalmic solut...
Enzyme-Induced Vitreolysis Can Alleviate the Progression of Diabetic Retinopathy Through the HIF-1{alpha} Pathway [Physiology and Pharmacology] 26 Jul 2013 | 09:45 pm
Purpose. We studied the mechanism by which complete posterior vitreous detachment by enzyme-induced vitreolysis alleviates the progression of diabetic retinopathy. Methods. We enrolled 50 diabetic ...
Associations With Retinal Nerve Fiber Layer Measures in the EPIC-Norfolk Eye Study [Clinical and Epidemiologic Research] 26 Jul 2013 | 09:45 pm
Purpose. To describe GDxVCC retinal nerve fiber layer (RNFL) measures and associations in a predominantly white British population. Methods. The EPIC-Norfolk Eye Study is nested within a large mult...
Extralenticular and Lenticular Aspects of Accommodation and Presbyopia in Human Versus Monkey Eyes [Lens] 26 Jul 2013 | 09:45 pm
Purpose. To determine if the accommodative forward movements of the vitreous zonule and lens equator occur in the human eye, as they do in the rhesus monkey eye; to investigate the connection between...
Accommodative Movements of the Vitreous Membrane, Choroid, and Sclera in Young and Presbyopic Human and Nonhuman Primate Eyes [Lens] 26 Jul 2013 | 09:45 pm
Purpose. We report, for the first time to our knowledge, dynamic movements of the vitreous membrane and peripheral choroid during accommodation, and age-related changes in the anterior sclera. Metho...
