Jbc - jbc.org - Journal of Biological Chemistry current issue
General Information:
Latest News:
One NSF, Different SNAREs: A t-SNARE-dependent Mechanism [Enzymology] 23 Aug 2013 | 06:32 pm
Vesicle trafficking in eukaryotic cells is facilitated by SNARE-mediated membrane fusion. The ATPase NSF (N-ethylmaleimide-sensitive factor) and the adaptor protein α-SNAP (soluble NSF attachment prot...
SSG1 Is a PKGI Substrate and Binding Protein [Molecular Bases of Disease] 23 Aug 2013 | 06:32 pm
NO, via its second messenger cGMP, activates protein kinase GI (PKGI) to induce vascular smooth muscle cell relaxation. The mechanisms by which PKGI kinase activity regulates cardiovascular function r...
Mtbhsp60 Targets TLR2 to Induce IL-10 [Cell Biology] 23 Aug 2013 | 06:32 pm
Understanding the signaling pathways involved in the regulation of anti-inflammatory and pro-inflammatory responses in tuberculosis is extremely important in tailoring a macrophage innate response to ...
Immunomodulation by Short and Long Chain n-Alkanols [Immunology] 23 Aug 2013 | 06:32 pm
Aliphatic n-alkanols are a family of ubiquitous substances that display general anesthetic properties in accordance to their degree of hydrophobicity. In addition, the immunomodulatory activity of one...
NO and Glutathione Transferase Evolution [Protein Structure and Folding] 23 Aug 2013 | 06:32 pm
Glutathione transferases (GSTs) are protection enzymes capable of conjugating glutathione (GSH) to toxic compounds. During evolution an important catalytic cysteine residue involved in GSH activation ...
Role of a Protein-tyrosine Phosphatase in Ovarian Cancer♦ [Papers of the Week] 23 Aug 2013 | 06:32 pm
♦ See referenced article, J. Biol. Chem. 2013, 288, 24923–24934 Ovarian cancer is the leading causing of death from gynecological malignancies and ranks fifth in all fatal cancer cases in women. Multi...
PTP1B Dephosphorylated and Inactivated Both BRK and IGF-1R [Gene Regulation] 23 Aug 2013 | 06:32 pm
Ovarian cancer, which is the leading cause of death from gynecological malignancies, is a heterogeneous disease known to be associated with disruption of multiple signaling pathways. Nevertheless, lit...
Wound Healing Regulated by NF{kappa}B-p50-activated CTCF [Molecular Bases of Disease] 23 Aug 2013 | 06:32 pm
Epidermal growth factor (EGF) plays an important role in corneal epithelial migration and proliferation to improve the wound healing process. This study aimed to understand the role of NFκB in EGF-ind...
PKC Signaling and Rat Embryonic Stem Cells [Developmental Biology] 23 Aug 2013 | 06:32 pm
Embryonic stem cell (ESC) pluripotency is orchestrated by distinct signaling pathways that are often targeted to maintain ESC self-renewal or their differentiation to other lineages. We showed earlier...
Contact Sites of Cell Division Proteins FtsB/FtsL on FtsQ [Protein Structure and Folding] 23 Aug 2013 | 06:32 pm
Escherichia coli cell division is effected by a large assembly of proteins called the divisome, of which a subcomplex consisting of three bitopic inner membrane proteins, FtsQ, FtsB, and FtsL, is an e...
