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Adipocyte iron regulates adiponectin and insulin sensitivity 30 Nov -0001 | 12:00 am
Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. In human...
Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning 30 Nov -0001 | 12:00 am
The transcription factor GATA-2 plays vital roles in quite diverse developmental programs, including hematopoietic stem cell (HSC) survival and proliferation. We previously identified a vascular endot...
Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity 30 Nov -0001 | 12:00 am
Haploinsufficiency for GATA2 causes human immunodeficiency syndromes characterized by mycobacterial infection, myelodysplasia, lymphedema, or aplastic anemia that progress to myeloid leukemia. GATA2 e...
Alveolar epithelial cells orchestrate DC function in murine viral pneumonia 30 Nov -0001 | 12:00 am
Influenza viruses (IVs) cause pneumonia in humans with progression to lung failure. Pulmonary DCs are key players in the antiviral immune response, which is crucial to restore alveolar barrier functio...
Complete Plasmodium falciparum liver stage development in liver-chimeric mice 30 Nov -0001 | 12:00 am
Plasmodium falciparum, which causes the most lethal form of human malaria, replicates in the host liver during the initial stage of infection. However, in vivo malaria liver-stage (LS) studies in huma...
NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors 30 Nov -0001 | 12:00 am
The formation of a long-lasting memory requires a transcription-dependent consolidation period that converts a short-term memory into a long-term memory. Nuclear receptors compose a class of transcrip...
MicroRNAs contribute to compensatory {beta} cell expansion during pregnancy and obesity 30 Nov -0001 | 12:00 am
Pregnancy and obesity are frequently associated with diminished insulin sensitivity, which is normally compensated for by an expansion of the functional β cell mass that prevents chronic hyperglycemia...
The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling 30 Nov -0001 | 12:00 am
The adenosine diphosphate (ADP) receptor P2RY12 (purinergic receptor P2Y, G protein coupled, 12) plays a critical role in platelet aggregation, and P2RY12 inhibitors are used clinically to prevent car...
Recombinant IL-7/HGF{beta} efficiently induces transplantable murine hematopoietic stem cells 30 Nov -0001 | 12:00 am
Difficulty obtaining sufficient hematopoietic stem cells (HSCs) directly from the donor has limited the clinical use of HSC transplantation. Numerous attempts to stimulate the ex vivo growth of purifi...
Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets 30 Nov -0001 | 12:00 am
Diabetes is a common comorbidity in cystic fibrosis (CF) that worsens prognosis. The lack of an animal model for CF-related diabetes (CFRD) has made it difficult to dissect how the onset of pancreatic...
