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Recombinant IL-7/HGF{beta} efficiently induces transplantable murine hematopoietic stem cells 30 Nov -0001 | 12:00 am
Difficulty obtaining sufficient hematopoietic stem cells (HSCs) directly from the donor has limited the clinical use of HSC transplantation. Numerous attempts to stimulate the ex vivo growth of purifi...
Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets 30 Nov -0001 | 12:00 am
Diabetes is a common comorbidity in cystic fibrosis (CF) that worsens prognosis. The lack of an animal model for CF-related diabetes (CFRD) has made it difficult to dissect how the onset of pancreatic...
CXCR1/2 inhibition enhances pancreatic islet survival after transplantation 30 Nov -0001 | 12:00 am
Although long considered a promising treatment option for type 1 diabetes, pancreatic islet cell transformation has been hindered by immune system rejection of engrafted tissue. The identification of ...
Myocardin regulates BMP10 expression and is required for heart development 30 Nov -0001 | 12:00 am
Myocardin is a muscle lineage–restricted transcriptional coactivator that has been shown to transduce extracellular signals to the nucleus required for SMC differentiation. We now report the discovery...
Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling 30 Nov -0001 | 12:00 am
The osteoporosis associated with human hyperthyroidism has traditionally been attributed to elevated thyroid hormone levels. There is evidence, however, that thyroid-stimulating hormone (TSH), which i...
Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression 30 Nov -0001 | 12:00 am
Huntington’s disease (HD) is a fatal, inherited neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Therapeutic approaches to lower mutant HTT (mHTT) lev...
TGF-{beta} induces miR-182 to sustain NF-κB activation in glioma subsets 30 Nov -0001 | 12:00 am
The strength and duration of NF-κB signaling are tightly controlled by multiple negative feedback mechanisms. However, in cancer cells, these feedback loops are overridden through unclear mechanisms t...
GATA4 and GATA6 control mouse pancreas organogenesis 30 Nov -0001 | 12:00 am
Recently, heterozygous mutations in GATA6 have been found in neonatal diabetic patients with failed pancreatic organogenesis. To investigate the roles of GATA4 and GATA6 in mouse pancreas organogenesi...
Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis 30 Nov -0001 | 12:00 am
Pancreatic agenesis is a human disorder caused by defects in pancreas development. To date, only a few genes have been linked to pancreatic agenesis in humans, with mutations in pancreatic and duodena...
Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration 30 Nov -0001 | 12:00 am
Hyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one of the leading causes of infertility in women aged 25–34. Hyperprolactinemia has been proposed to block ovulation...
