Vitamin E: the enigmatic one! [Thematic Reviews] 7 Aug 2013 | 08:05 pm

Mechanisms for the prevention of vitamin E excess [Thematic Reviews] 7 Aug 2013 | 08:05 pm

The liver is at the nexus of the regulation of lipoprotein uptake, synthesis, and secretion, and it is the site of xenobiotic detoxification by cytochrome P450 oxidation systems (phase I), conjugation...

Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection [Thematic Reviews] 7 Aug 2013 | 08:05 pm

Vitamin E is a naturally occurring fat-soluble antioxidant which has been proposed as a treatment for both primary and secondary protection against cardiovascular (CV) events. Promising data from obse...

Regulation of signal transduction by HDL [Thematic Reviews] 7 Aug 2013 | 08:05 pm

High density lipoprotein (HDL) cholesterol has direct effects on numerous cell types that influence cardiovascular and metabolic health. These include endothelial cells, vascular smooth-muscle cells, ...

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism [Reviews] 7 Aug 2013 | 08:05 pm

Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on mammalian energy met...

Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys [Research Arti... 7 Aug 2013 | 08:05 pm

MDCO-216, a complex of dimeric recombinant apoA-IMilano (apoA-IM) and palmitoyl-oleoyl-phosphatidylcholine (POPC), was administered to cynomolgus monkeys at 30, 100, and 300 mg/kg every other day for ...

Divergence between human and murine peroxisome proliferator-activated receptor alpha ligand specificities [Research Articles] 7 Aug 2013 | 08:05 pm

Peroxisome proliferator-activated receptor α (PPARα) belongs to the family of ligand-dependent nuclear transcription factors that regulate energy metabolism. Although there exists remarkable overlap i...

Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by pa... 7 Aug 2013 | 08:05 pm

Chronic exposure of skeletal muscle to saturated fatty acids, such as palmitate (C16:0), enhances proinflammatory IKK-NFB signaling by a mechanism involving the MAP kinase (Raf-MEK-ERK) pathway. Raf a...

Lipid transfer particle from the silkworm, Bombyx mori, is a novel member of the apoB/large lipid transfer protein family [Research Articles] 7 Aug 2013 | 08:05 pm

Lipid transfer particle (LTP) is a high-molecular-weight, very high-density lipoprotein known to catalyze the transfer of lipids between a variety of lipoproteins, including both insects and vertebrat...

Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPAR{gamma} activity [Research Articles] 7 Aug 2013 | 08:05 pm

Adipocyte differentiation is a multistep program under regulation by several factors. Peroxisome proliferator-activated receptor (PPAR) serves as a master regulator of adipogenesis. However, the endog...