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Correlation between centromere protein-F autoantibodies and cancer analyzed by enzyme-linked immunosorbent assay 26 Aug 2013 | 05:00 am
Background: Centromere protein-F (CENP-F) is a large nuclear protein of 367 kDa, which is involved in multiple mitosis-related events such as proper assembly of the kinetochores, stabilization of hete...
Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes 16 Aug 2013 | 05:00 am
Ionizing radiation (IR) is used for patients diagnosed with unresectable non small cell lung cancer (NSCLC), however radiotherapy remains largely palliative due to radioresistance. Cancer stem cells (...
The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells 14 Aug 2013 | 05:00 am
Background: In eukaryotes, miR-16 is an important microRNA (miRNA) that is involved in numerous biological processes. However, it is not fully understood how miR-16 executes its physiological function...
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses 14 Aug 2013 | 05:00 am
Abnormal rates of growth together with metastatic potential and lack of susceptibility to cellular signals leading to apoptosis are widely investigated characteristics of tumors that develop via genet...
USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy 10 Aug 2013 | 05:00 am
Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis, and the enzymes that participate in this process, in particular E3 ubiquitin ligases and deubiquitinase...
Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung ca... 6 Aug 2013 | 05:00 am
Background: Farnesyltransferase inhibitors (FTIs) are anticancer agents with a spectrum of activity in Ras-dependent and independent tumor cellular and xenograph models. How inhibition of protein farn...
Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts 6 Aug 2013 | 05:00 am
Background: Krüppel-like factor 4 (KLF4) is a member of the KLF family of transcription factors and regulates proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also su...
Cigarette smoke induces epithelial to mesenchymal transition and increases the metastatic ability of breast cancer cells 6 Aug 2013 | 05:00 am
Background: Recent epidemiological studies demonstrate that both active and involuntary exposure to tobacco smoke increase the risk of breast cancer. Little is known, however, about the molecular mech...
Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma 5 Aug 2013 | 05:00 am
Background: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 ...
The complexity of NF-kappaB signaling in inflammation and cancer 2 Aug 2013 | 05:00 am
The NF-kappaB family of transcription factors has an essential role in inflammation and innate immunity. Furthermore, NF-kappaB is increasingly recognized as a crucial player in many steps of cancer i...
