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The Alcohol Improvement Programme: Evaluation of an Initiative to Address Alcohol-Related Health Harm in England 19 Aug 2013 | 09:08 pm
Aims: The evaluation aimed to assess the impact of The Alcohol Improvement Programme (AIP). This was a UK Department of Health initiative (April 2008–March 2011) aiming to contribute to the reduction ...
Improved Drinking Behaviour Improves Quality of Life: A Follow-Up in Alcohol-Dependent Subjects 7 Years After Treatment 19 Aug 2013 | 09:08 pm
Aim: The present study relates alcohol-dependent patients' Quality of Life (QoL) 7 years after treatment to drinking status as the conventional endpoint of trials. Potential moderating factors such as...
Efficacy of As-Needed Nalmefene in Alcohol-Dependent Patients with at Least a High Drinking Risk Level: Results from a Subgroup Analysis of Two Random... 19 Aug 2013 | 09:08 pm
Aims: The aim of the study was to investigate the efficacy and safety of as-needed use of nalmefene 18 mg versus placebo in reducing alcohol consumption in patients who did not reduce their alcohol co...
Prevalence of Hepatitis C Virus Infection in Alcoholic Patients: Cohort Study and Systematic Review 19 Aug 2013 | 09:08 pm
Aims: Prevalence of chronic hepatitis C virus (HCV) infection among alcoholics is thought to be higher than in the general population, although prevalence rates reported are quite variable. Our study ...
Quantification of Ethyl Glucuronide in Hair: Effect of Milling on Extraction Efficiency 19 Aug 2013 | 09:08 pm
Aim: The objective of the study was to provide conclusive evidence for the effect of particle size reduction as by milling on the extractable content of ethyl glucuronide (EtG) of hair samples. Method...
Reduced Intra-individual Reaction Time Variability During a Go-NoGo Task in Detoxified Alcohol-Dependent Patients After One Right-Sided Dorsolateral P... 19 Aug 2013 | 09:08 pm
Aims: As alcohol dependency is characterized by severe executive function deficits, we examined the influence of high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) applied to the ...
Metabolic Abnormalities in Lobar and Subcortical Brain Regions of Abstinent Polysubstance Users: Magnetic Resonance Spectroscopic Imaging 19 Aug 2013 | 09:08 pm
Aims: The aim of the study was to explore neurometabolic and associated cognitive characteristics of patients with polysubstance use (PSU) in comparison with patients with predominant alcohol use usin...
Relationship Between Alcohol Intake and Lipid Accumulation Product in Middle-aged Men 19 Aug 2013 | 09:08 pm
Aims: Lipid accumulation product (LAP), defined as a product of waist circumference and triglycerides, has recently been proposed as a predictor of cardiovascular disease and diabetes mellitus. The pu...
Sulforaphane Accelerates Acetaldehyde Metabolism by Inducing Aldehyde Dehydrogenases: Relevance to Ethanol Intolerance 19 Aug 2013 | 09:08 pm
Aims: Many East Asians are highly intolerant to even modest alcohol consumption. These individuals accumulate acetaldehyde, the primary metabolite of ethanol, because of a genetic polymorphism of alde...
{micro}-Opioid Receptor Gene (OPRM1) Polymorphism A118G: Lack of Association in Finnish Populations with Alcohol Dependence or Alcohol Consumption 19 Aug 2013 | 09:08 pm
Aims: The molecular epidemiological studies on the association of the opioid receptor µ-1 (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) and alcohol use disorders have given conflicting results. The...
