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Comparability and reproducibility of biomedical data 17 Jul 2013 | 06:09 pm
With the development of novel assay technologies, biomedical experiments and analyses have gone through substantial evolution. Today, a typical experiment can simultaneously measure hundreds to thousa...
On the classification of microarray gene-expression data 17 Jul 2013 | 06:09 pm
We consider the classification of microarray gene-expression data. First, attention is given to the supervised case, where the tissue samples are classified with respect to a number of predefined clas...
Mathematical modeling of biological systems 17 Jul 2013 | 06:09 pm
Mathematical and computational models are increasingly used to help interpret biomedical data produced by high-throughput genomics and proteomics projects. The application of advanced computer models ...
Accounting for noise when clustering biological data 17 Jul 2013 | 06:09 pm
Clustering is a powerful and commonly used technique that organizes and elucidates the structure of biological data. Clustering data from gene expression, metabolomics and proteomics experiments has p...
A practical guide for the functional annotation of genetic variations using SNPnexus 17 Jul 2013 | 06:09 pm
Broader functional annotation of known as well as putative genetic variations is a valuable mean for prioritizing targets in disease studies and large-scale genotyping projects. In this article, we pr...
Congruency in the prediction of pathogenic missense mutations: state-of-the-art web-based tools 17 Jul 2013 | 06:09 pm
A remarkable degree of genetic variation has been found in the protein-encoding regions of DNA through deep sequencing of samples obtained from thousands of subjects from several populations. Approxim...
A multivalent three-point linkage analysis model of autotetraploids 17 Jul 2013 | 06:09 pm
Because of its widespread occurrence and role in shaping evolutionary processes in the biological kingdom, especially in plants, polyploidy has been increasingly studied from cytological to molecular ...
Batch effect removal methods for microarray gene expression data integration: a survey 17 Jul 2013 | 06:09 pm
Genomic data integration is a key goal to be achieved towards large-scale genomic data analysis. This process is very challenging due to the diverse sources of information resulting from genomics expe...
Network-based drug discovery by integrating systems biology and computational technologies 17 Jul 2013 | 06:09 pm
Network-based intervention has been a trend of curing systemic diseases, but it relies on regimen optimization and valid multi-target actions of the drugs. The complex multi-component nature of medici...
Application of next generation sequencing to human gene fusion detection: computational tools, features and perspectives 17 Jul 2013 | 06:09 pm
Gene fusions are important genomic events in human cancer because their fusion gene products can drive the development of cancer and thus are potential prognostic tools or therapeutic targets in anti-...
