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Computational methods to detect conserved non-genic elements in phylogenetically isolated genomes: application to zebrafish 27 Aug 2013 | 12:04 pm
Many important model organisms for biomedical and evolutionary research have sequenced genomes, but occupy a phylogenetically isolated position, evolutionarily distant from other sequenced genomes. Th...
Co-expression of RNA-protein complexes in Escherichia coli and applications to RNA biology 27 Aug 2013 | 12:04 pm
RNA has emerged as a major player in many cellular processes. Understanding these processes at the molecular level requires homogeneous RNA samples for structural, biochemical and pharmacological stud...
SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins 27 Aug 2013 | 12:04 pm
Selenoproteins are proteins containing an uncommon amino acid selenocysteine (Sec). Sec is inserted by a specific translational machinery that recognizes a stem-loop structure, the SECIS element, at t...
Rapid oligonucleotide-templated fluorogenic tetrazine ligations 27 Aug 2013 | 12:04 pm
Template driven chemical ligation of fluorogenic probes represents a powerful method for DNA and RNA detection and imaging. Unfortunately, previous techniques have been hampered by requiring chemistry...
miRspring: a compact standalone research tool for analyzing miRNA-seq data 27 Aug 2013 | 12:04 pm
High-throughput sequencing for microRNA (miRNA) profiling has revealed a vast complexity of miRNA processing variants, but these are difficult to discern for those without bioinformatics expertise and...
Integrated analysis of microRNA and mRNA expression: adding biological significance to microRNA target predictions 27 Aug 2013 | 12:04 pm
Current microRNA target predictions are based on sequence information and empirically derived rules but do not make use of the expression of microRNAs and their targets. This study aimed to improve mi...
Whole-body scanning PCR; a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides 27 Aug 2013 | 12:04 pm
Efficient tissue-specific delivery is a crucial factor in the successful development of therapeutic oligonucleotides. Screening for novel delivery methods with unique tissue-homing properties requires...
