Oxfordjournals - ndt.oxfordjournals.org - Nephrology Dialysis Transplantation - current issue
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Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patients with IgA nephropathy 10 Jul 2013 | 08:17 pm
Background It has been reported that podocytopenia has been occurring with increasing disease severity in patients with IgA nephropathy (IgAN). Dendrin is localized at the slit diaphragm (SD) in podo...
Validation of the kidney failure risk equation in European CKD patients 10 Jul 2013 | 08:17 pm
Background Patients with chronic kidney disease (CKD) are at risk for progression to kidney failure. Using data of Canadian CKD patients, Tangri et al. recently developed models to predict the progre...
Cholecalciferol in haemodialysis patients: a randomized, double-blind, proof-of-concept and safety study 10 Jul 2013 | 08:17 pm
Background The role of cholecalciferol supplementation in end-stage renal disease (ESRD) patients has been questioned. The objective of this randomized double-blinded study is to assess whether chole...
Regression of left ventricular hypertrophy in patients with primary aldosteronism/low-renin hypertension on low-dose spironolactone 10 Jul 2013 | 08:17 pm
Background The incidence of left ventricular hypertrophy (LVH) in primary aldosteronism (PA) is higher than in essential hypertension. LVH is an independent cardiovascular risk factor. Treatment of P...
Isolated microalbuminuria indicates a poor medical prognosis 10 Jul 2013 | 08:17 pm
Background Microalbuminuria is often regarded as a sign of end-organ damage due to diabetes and/or hypertension, and as such to be associated with an increased risk for cardiovascular events. It has ...
Kidney-protective effects of azelnidipine versus a diuretic in combination with olmesartan in hypertensive patients with diabetes and albuminuria: a r... 10 Jul 2013 | 08:17 pm
Background A thiazide diuretic used in combination with benazepril is superior to amlodipine plus benazepril in reducing albuminuria in hypertensive patients with diabetes. However, calcium channel b...
Decline in renal functioning is associated with longitudinal decline in global cognitive functioning, abstract reasoning and verbal memory 10 Jul 2013 | 08:17 pm
Background Decreased estimated glomerular filtration rate (eGFR) and higher serum creatinine (sCR) levels have been associated with longitudinal decline in global mental status measures. Longitudinal...
The association between cystatin C and incident type 2 diabetes is related to central adiposity 10 Jul 2013 | 08:17 pm
Background Cystatin C has recently been shown to be associated with incident type 2 diabetes. This study aims to validate this association and to study the impact of baseline adiposity. Methods We ...
New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis 10 Jul 2013 | 08:17 pm
Background Focal segmental glomerulosclerosis (FSGS) is a leading cause of steroid-resistant nephrotic syndrome. Hereditary FSGS is frequently caused by mutations in important structural podocyte pro...
Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy 10 Jul 2013 | 08:17 pm
Background Antibodies against M-type phospholipase A2 receptor (PLA2R) are serological markers of disease activity in patients with idiopathic membranous nephropathy (iMN). To determine the most sens...
