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Metal Allergens Induce Nitric Oxide Production by Mouse Dermal Fibroblasts via the Hypoxia-Inducible Factor-2{alpha}-Dependent Pathway 21 Aug 2013 | 02:34 pm
Nickel (Ni) has been shown to be one of the most frequent metal allergens. We have already reported a murine metal allergy model with pathogen-associated molecular patterns (PAMPs) as adjuvants. Inter...
The Fas/Fas Ligand Apoptotic Pathway Is Involved in Abrin-Induced Apoptosis 21 Aug 2013 | 02:34 pm
Abrin is a plant glycoprotein toxin from the seeds of Abrus precatorius, sharing similarity in structure and properties with ricin. Abrin is highly toxic, with an estimated human fatal dose of 0.1–1 µ...
Studies in Experimental Autoimmune Encephalomyelitis Do Not Support Developmental Bisphenol A Exposure as an Environmental Factor in Increasing Multip... 21 Aug 2013 | 02:34 pm
Multiple sclerosis (MS), a demyelinating immune-mediated central nervous system disease characterized by increasing female penetrance, is the leading cause of disability in young adults in the develop...
Suppression of Acute Graft-Versus-Host Response by TCDD Is Independent of the CTLA-4-IFN-{gamma}-IDO pathway 21 Aug 2013 | 02:34 pm
Activation of the aryl hydrocarbon receptor (AhR) by its prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induces potent suppression of an acute graft-versus-host (GVH) response and prev...
A Synergistic Vascular Effect of Airborne Particulate Matter and Nickel in a Mouse Model 21 Aug 2013 | 02:34 pm
Both epidemiological and empirical studies have indicated that nickel (Ni) may play an important role in PM2.5 exposure–induced adverse cardiovascular effects. However, the underlying mechanism remain...
Altered miRNA Expression Profiles and miR-1a Associated With Urethane-Induced Pulmonary Carcinogenesis 21 Aug 2013 | 02:34 pm
MicroRNAs (miRNAs) are small RNA molecules that regulate posttranscriptional gene expression. Previous research has suggested that aberrant miRNA expression often plays a critical role in many types o...
Impact of Pregnancy on the Pharmacokinetics of Dibenzo[def,p]chrysene in Mice 21 Aug 2013 | 02:34 pm
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants generated during combustion. Dibenzo[def,p]chrysene (DBC) is a high molecular weight PAH classified as a 2B carcinogen...
Identification of 2-Piperidone as a Biomarker of CYP2E1 Activity Through Metabolomic Phenotyping 21 Aug 2013 | 02:34 pm
Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the metabolic activation of many low molecular weight toxicants and also an important contributor to oxidative stress. A noninvasive method to monitor C...
Hepatocyte Growth Factor Protects Against Isoniazid/Rifampicin-Induced Oxidative Liver Damage 21 Aug 2013 | 02:34 pm
The worldwide increment of multidrug- and extensively drug-resistant tuberculosis has emphasized the importance of looking for new options in therapeutics. Long-time usage or higher doses of isoniazid...
Increases in Oxidized Low-Density Lipoprotein and Other Inflammatory and Adhesion Molecules With a Concomitant Decrease in High-Density Lipoprotein in... 21 Aug 2013 | 02:34 pm
Elevated exposure to arsenic has been suggested to be associated with atherosclerosis leading to cardiovascular disease (CVD). However, biochemical events underlying the arsenic-induced atherosclerosi...
