Civil, sensible, and constructive peer review in APS journals 1 Aug 2013 | 09:00 pm

Validity of the doubly labeled water method for estimating CO2 production in mice under different nutritional conditions 1 Aug 2013 | 09:00 pm

The doubly labeled water (DLW) technique is used to assess metabolic rate (MR) in free-living conditions. We investigated whether differences in the nutritional and body adiposity status affect validi...

Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells 1 Aug 2013 | 09:00 pm

In somatic cells, a collection of signaling pathways activated by amino acid limitation have been identified and referred to as the amino acid response (AAR). Despite the importance of possible detrim...

Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake 1 Aug 2013 | 09:00 pm

Carnitine palmitoyltransferase-1 (CPT-1) liver isoform, or CPT-1a, is implicated in CNS control of food intake. However, the exact brain nucleus site(s) in mediating this action of CPT-1a has not been...

Goldfish spexin: solution structure and novel function as a satiety factor in feeding control 1 Aug 2013 | 09:00 pm

Spexin (SPX) is a neuropeptide identified recently by bioinformatic approach. At present not much is known about its biological actions, and comparative studies of SPX in nonmammalian species are stil...

Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis 1 Aug 2013 | 09:00 pm

In catabolic conditions such as aging and diabetes, IGF signaling is impaired and fibrosis develops in skeletal muscles. To examine whether impaired IGF signaling initiates muscle fibrosis, we generat...

Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways 1 Aug 2013 | 09:00 pm

We previously reported that glucagon-like peptide-1 (GLP-1) appearance in the portal vein facilitates hepatic vagal afferent activity, and this further augments reflexively the pancreatic vagal effere...

Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance 1 Aug 2013 | 09:00 pm

High-fat feeding for 3–4 days impairs glucose tolerance and hepatic insulin sensitivity. However, it remains unclear whether the evolving hepatic insulin resistance is due to acute lipid overload or t...

Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats 1 Aug 2013 | 09:00 pm

Evidence for an important role for Na+/H+ exchangers in diabetic complications is emerging. The aim of this study was to evaluate whether Na+/H+ exchanger 1 inhibition reverses experimental peripheral...

Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production 1 Aug 2013 | 09:00 pm

Enhancement of proton leaks in muscle tissue represents a potential target for obesity treatment. In this study, we examined the bioenergetic and physiological implications of increased proton leak in...