Civil, sensible, and constructive peer review in APS journals 1 Aug 2013 | 09:00 pm

Mammalian colonocytes possess a carrier-mediated mechanism for uptake of vitamin B3 (niacin): studies utilizing human and mouse colonic preparations 1 Aug 2013 | 09:00 pm

Niacin (vitamin B3; nicotinic acid) plays an important role in maintaining redox state of cells and is obtained from endogenous and exogenous sources. The latter source has generally been assumed to b...

CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism 1 Aug 2013 | 09:00 pm

CTRP3 is a secreted plasma protein of the C1q family that helps regulate hepatic gluconeogenesis and is downregulated in a diet-induced obese state. However, the role of CTRP3 in regulating lipid meta...

Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response 1 Aug 2013 | 09:00 pm

l -Arginine ( l -Arg) is a semiessential amino acid that has altered availability in human ulcerative colitis (UC), a form of inflammatory bowel disease, and is beneficial in murine colitis induced by...

Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/{beta}-catenin signaling 1 Aug 2013 | 09:00 pm

Heparan sulfate (HS), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. HSPGs modulate functions of several growth factors and signaling molecules. We ...

Neuropeptide Y inhibits biliary hyperplasia of cholestatic rats by paracrine and autocrine mechanisms 1 Aug 2013 | 09:00 pm

Neuropeptide Y (NPY) exerts its functions through six subtypes of receptors (Y1–Y6). Biliary homeostasis is regulated by several factors through autocrine/paracrine signaling. NPY inhibits cholangioca...

Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport 1 Aug 2013 | 09:00 pm

The Brunner's glands of the proximal duodenum exert barrier functions through secretion of glycoproteins and antimicrobial peptides. However, ion transporter localization, function, and regulation in ...

Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells 15 Jul 2013 | 09:00 pm

Chronic infection of the gastric mucosa by Helicobacter pylori is associated with an increased risk of developing gastric cancer; however, the vast majority of infected individuals never develop this ...

Corrigendum 15 Jul 2013 | 09:00 pm

Translational aspects of rectal evoked potentials: a comparative study in rats and humans 15 Jul 2013 | 09:00 pm

Inconsistencies between species has stunted the progress of developing new analgesics. To increase the success of translating results between species, improved comparable models are required. Twelve r...