MicroRNAs in domestic livestock 15 Aug 2013 | 09:00 pm

microRNAs (miRNAs) are a class of small noncoding RNA that bind to complementary sequences in the untranslated regions of multiple target mRNAs resulting in posttranscriptional regulation of gene expr...

Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis 15 Aug 2013 | 09:00 pm

Inflammatory cross talk between perivascular adipose tissue and the blood vessel wall has been proposed to contribute to the pathogenesis of atherosclerosis. We previously reported that human perivasc...

Comprehensive genomic profiling in diabetic nephropathy reveals the predominance of proinflammatory pathways 15 Aug 2013 | 09:00 pm

Despite advances in the treatment of diabetic nephropathy (DN), currently available therapies have not prevented the epidemic of progressive chronic kidney disease (CKD). The morbidity of CKD, and the...

SORCS1 contributes to the development of renal disease in rats and humans 15 Aug 2013 | 09:00 pm

Many lines of evidence demonstrate that genetic variability contributes to chronic kidney disease susceptibility in humans as well as rodent models. Little progress has been made in discovering causal...

Isolation and high-throughput sequencing of two closely linked epistatic hypertension susceptibility loci with a panel of bicongenic strains 15 Aug 2013 | 09:00 pm

Interactions or epistasis between genetic factors may contribute to "missing heritability." While linkage analyses detect epistasis, defining the limits of the interacting segments poses a significant...

Theoretical model for gene-gene, gene-environment, and gene-sex interactions based on congenic-strain analysis of blood pressure in Dahl salt-sensitiv... 15 Aug 2013 | 09:00 pm

There is a significant literature describing quantitative trait loci (QTL) controlling blood pressure (BP) in the Dahl salt-sensitive (S) rat. In studies to identify the genes underlying BP QTL it has...

Civil, sensible, and constructive peer review in APS journals 1 Aug 2013 | 09:00 pm

Bovine TB in livestock and wildlife: what's in the genes? 1 Aug 2013 | 09:00 pm

Bovine tuberculosis (BTB) is a chronic, infectious disease found in domestic livestock and wildlife. It is caused predominantly by Mycobacterium bovis, which forms part of the Mycobacterium tuberculos...

Neural control hierarchy of the heart has not evolved to deal with myocardial ischemia 1 Aug 2013 | 09:00 pm

The consequences of myocardial ischemia are examined from the standpoint of the neural control system of the heart, a hierarchy of three neuronal centers residing in central command, intrathoracic gan...

Leptin gene in rabbit: cloning and expression in mammary epithelial cells during pregnancy and lactation 1 Aug 2013 | 09:00 pm

Leptin is known as a cytokine mostly produced by fat cells and implicated in regulation of energy metabolism and food intake but has also been shown to be involved in many physiological mechanisms suc...