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International Society for Computational Biology Welcomes Its Newest Class of Fellows 23 Aug 2013 | 02:00 am
by Christiana N. Fogg, Diane E. Kovats
Gause's Principle and the Effect of Resource Partitioning on the Dynamical Coexistence of Replicating Templates 23 Aug 2013 | 02:00 am
by András Szilágyi, István Zachar, Eörs Szathmáry Models of competitive template replication, although basic for replicator dynamics and primordial evolution, have not yet taken different sequences e...
On the Importance of Polar Interactions for Complexes Containing Intrinsically Disordered Proteins 23 Aug 2013 | 02:00 am
by Eric T. C. Wong, Dokyun Na, Jörg Gsponer There is a growing recognition for the importance of proteins with large intrinsically disordered (ID) segments in cell signaling and regulation. ID segmen...
Predicting Disease Risk Using Bootstrap Ranking and Classification Algorithms 23 Aug 2013 | 02:00 am
by Ohad Manor, Eran Segal Genome-wide association studies (GWAS) are widely used to search for genetic loci that underlie human disease. Another goal is to predict disease risk for different individu...
Causes and Consequences of Hyperexcitation in Central Clock Neurons 23 Aug 2013 | 02:00 am
by Casey O. Diekman, Mino D. C. Belle, Robert P. Irwin, Charles N. Allen, Hugh D. Piggins, Daniel B. Forger Hyperexcited states, including depolarization block and depolarized low amplitude membrane ...
Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis 23 Aug 2013 | 02:00 am
by Jordi Heijman, Antonio Zaza, Daniel M. Johnson, Yoram Rudy, Ralf L. M. Peeters, Paul G. A. Volders, Ronald L. Westra Beat-to-beat variability of repolarization duration (BVR) is an intrinsic chara...
Transcriptional Regulation of Lineage Commitment - A Stochastic Model of Cell Fate Decisions 23 Aug 2013 | 02:00 am
by Jose Teles, Cristina Pina, Patrik Edén, Mattias Ohlsson, Tariq Enver, Carsten Peterson Molecular mechanisms employed by individual multipotent cells at the point of lineage commitment remain large...
A Self-Directed Method for Cell-Type Identification and Separation of Gene Expression Microarrays 23 Aug 2013 | 02:00 am
by Neta S. Zuckerman, Yair Noam, Andrea J. Goldsmith, Peter P. Lee Gene expression analysis is generally performed on heterogeneous tissue samples consisting of multiple cell types. Current methods d...
Nucleosome Free Regions in Yeast Promoters Result from Competitive Binding of Transcription Factors That Interact with Chromatin Modifiers 23 Aug 2013 | 02:00 am
by Evgeniy A. Ozonov, Erik van Nimwegen Because DNA packaging in nucleosomes modulates its accessibility to transcription factors (TFs), unraveling the causal determinants of nucleosome positioning i...
Stochasticity, Bistability and the Wisdom of Crowds: A Model for Associative Learning in Genetic Regulatory Networks 23 Aug 2013 | 02:00 am
by Matan Sorek, Nathalie Q. Balaban, Yonatan Loewenstein It is generally believed that associative memory in the brain depends on multistable synaptic dynamics, which enable the synapses to maintain ...
