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The Architecture of a Prototypical Bacterial Signaling Circuit Enables a Single Point Mutation to Confer Novel Network Properties 23 Aug 2013 | 02:00 am
by Sri Ram, Mark Goulian Even a single mutation can cause a marked change in a protein's properties. When the mutant protein functions within a network, complex phenotypes may emerge that are not int...
The Intronic Long Noncoding RNA ANRASSF1 Recruits PRC2 to the RASSF1A Promoter, Reducing the Expression of RASSF1A and Increasing Cell Proliferation 23 Aug 2013 | 02:00 am
by Felipe C. Beckedorff, Ana C. Ayupe, Renan Crocci-Souza, Murilo S. Amaral, Helder I. Nakaya, Daniela T. Soltys, Carlos F. M. Menck, Eduardo M. Reis, Sergio Verjovski-Almeida The down-regulation of ...
H2A.Z Acidic Patch Couples Chromatin Dynamics to Regulation of Gene Expression Programs during ESC Differentiation 23 Aug 2013 | 02:00 am
by Vidya Subramanian, Aprotim Mazumder, Lauren E. Surface, Vincent L. Butty, Paul A. Fields, Allison Alwan, Lillian Torrey, Kevin K. Thai, Stuart S. Levine, Mark Bathe, Laurie A. Boyer The histone H2...
Fifty Years On: GWAS Confirms the Role of a Rare Variant in Lung Disease 23 Aug 2013 | 02:00 am
by Alice M. Turner
The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1 23 Aug 2013 | 02:00 am
by Monique N. O'Leary, Katherine H. Schreiber, Yong Zhang, Anne-Cécile E. Duc, Shuyun Rao, J. Scott Hale, Emmeline C. Academia, Shreya R. Shah, John F. Morton, Carly A. Holstein, Dan B. Martin, Matt K...
Hard Selective Sweep and Ectopic Gene Conversion in a Gene Cluster Affording Environmental Adaptation 23 Aug 2013 | 02:00 am
by Marc Hanikenne, Juergen Kroymann, Aleksandra Trampczynska, María Bernal, Patrick Motte, Stephan Clemens, Ute Krämer Among the rare colonizers of heavy-metal rich toxic soils, Arabidopsis halleri i...
Histone Variant HTZ1 Shows Extensive Epistasis with, but Does Not Increase Robustness to, New Mutations 23 Aug 2013 | 02:00 am
by Joshua B. Richardson, Locke D. Uppendahl, Maria K. Traficante, Sasha F. Levy, Mark L. Siegal Biological systems produce phenotypes that appear to be robust to perturbation by mutations and environ...
Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes 23 Aug 2013 | 02:00 am
by Slavé Petrovski, Quanli Wang, Erin L. Heinzen, Andrew S. Allen, David B. Goldstein A central challenge in interpreting personal genomes is determining which mutations most likely influence disease...
Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen 23 Aug 2013 | 02:00 am
by Travis J. Wiles, J. Paul Norton, Colin W. Russell, Brian K. Dalley, Kael F. Fischer, Matthew A. Mulvey Strains of Extraintestinal Pathogenic Escherichia coli (ExPEC) exhibit an array of virulence ...
Chromatin Sampling—An Emerging Perspective on Targeting Polycomb Repressor Proteins 23 Aug 2013 | 02:00 am
by Robert J. Klose, Sarah Cooper, Anca M. Farcas, Neil P. Blackledge, Neil Brockdorff
