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The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles 19 Aug 2013 | 06:10 pm
Synaptic vesicles (SVs) fuse at a specialized membrane domain called the active zone (AZ), covered by a conserved cytomatrix. How exactly cytomatrix components intersect with SV release remains insuff...
The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1 19 Aug 2013 | 06:10 pm
Although much is known about signaling factors downstream of Rho GTPases that contribute to epidermal differentiation, little is known about which upstream regulatory proteins (guanine nucleotide exch...
Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex 19 Aug 2013 | 06:10 pm
Amniote epiblast cells differentiate into mesoderm and endoderm lineages during gastrulation through a process called epithelial-to-mesenchymal transition (EMT). Molecular regulation of gastrulation E...
Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase 19 Aug 2013 | 06:10 pm
The central spindle is built during anaphase by coupling antiparallel microtubules (MTs) at a central overlap zone, which provides a signaling scaffold for the regulation of cytokinesis. The mechanism...
Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A 19 Aug 2013 | 06:10 pm
Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than ...
Jody Rosenblatt: To extrude apically or basally, that is the question 19 Aug 2013 | 06:10 pm
<p>The primary function of epithelia is to serve as a barrier between a tissue and the surrounding environment. To preserve the integrity of the epithelial sheet, therefore, a dying epithelial cell is...
Aurora B helps the central spindle measure up 19 Aug 2013 | 06:10 pm
<p>During anaphase, cells assemble a central spindle between the segregating chromosomes. Microtubule plus ends overlap in the middle of the cell, creating a spindle midzone that recruits factors invo...
Phosphorylation helps Atg18 get the vacuole in shape 19 Aug 2013 | 06:10 pm
Low (left) and high (right) glucose levels alter the morphology of the vacuole (red) by regulating the phosphorylation of Atg18 (green). Tamura et al. describe how phosphorylation modulates the phosp...
Bruchpilot readies synaptic vesicles for release 19 Aug 2013 | 06:10 pm
Super resolution microscopy shows how clusters of two BRP isoforms (green and magenta) alternate within the T bars of fly synapses. Matkovic et al. describe how a protein matrix may position synaptic...
Epiblast cells CLASP onto the basement membrane 19 Aug 2013 | 06:10 pm
The basement membrane (red) is maintained underneath primitive streak epiblasts overexpressing CLASP1α (green). Nakaya et al. reveal how the microtubule plus-end tracking protein CLASP and the adhesi...
