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Neonatal MK-801 treatment differentially alters the effect of adolescent or adult MK-801 challenge on locomotion and PPI in male and female rats 27 Aug 2013 | 01:26 pm
Schizophrenia is a neurodevelopmental disorder and is typically "triggered" by subsequent insults in life. The N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) induces locomotor hy...
Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-... 27 Aug 2013 | 01:26 pm
Recent studies have indicated that the insula underlies affective learning. Although affective learning is well-established in the development of opiate addiction, the role of insula in this context r...
High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: Neural consequences and comparison with methamphetamine 27 Aug 2013 | 01:26 pm
Mephedrone (MMC) is a relatively new recreational drug that has rapidly increased in popularity in recent years. This study explored the characteristics of intravenous MMC self-administration in the r...
4-Methyl-amphetamine: a health threat for recreational amphetamine users 27 Aug 2013 | 01:26 pm
4-Methylamphetamine (4-MA) was originally developed as an appetite suppressant, but development was halted due to side effects. It has recently resurfaced as a new psychoactive substance in Europe, an...
Attractiveness of reformulated OxyContin(R) tablets: assessing comparative preferences and tampering potential 27 Aug 2013 | 01:26 pm
Reformulated OxyContin® (oxycodone HCl controlled-release or ORF) was developed as a tamper and abuse-deterrent product, to reduce the risk of product abuse, misuse and their consequences. This nonint...
Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects 27 Aug 2013 | 01:26 pm
Key characteristics of cocaine dependence include attentional bias to cocaine cues and impaired inhibitory control. Studies suggest that serotonin modulates both cocaine cue reactivity and inhibitory ...
Baseline dependency of nicotine's sensory gating actions: similarities and differences in low, medium and high P50 suppressors 27 Aug 2013 | 01:26 pm
Reduced suppression of the P50 auditory event-related potential in schizophrenia patients relative to normal controls is indicative of a sensory gating deficit and is one of the most robust findings r...
Electrophysiological indices of response inhibition in human polydrug users 27 Aug 2013 | 01:26 pm
Previous research in ecstasy users suggests impairment of various executive functions. In general, the executive function of response inhibition appears unaffected by ecstasy use. Nonetheless, it rema...
Psychiatry's next top model: cause for a re-think on drug models of psychosis and other psychiatric disorders 27 Aug 2013 | 01:26 pm
Despite the widespread application of drug modelling in psychiatric research, the relative value of different models has never been formally compared in the same analysis. Here we compared the effects...
The size, burden and cost of disorders of the brain in the UK 27 Aug 2013 | 01:26 pm
Aim: The aim of this paper is to increase awareness of the prevalence and cost of psychiatric and neurological disorders (brain disorders) in the UK. Method: UK data for 18 brain disorders were ext...
