Extrapolation of Survival Data in Cost-effectiveness Analyses: Improving the Current State of Play 18 Jul 2013 | 12:06 am

Survival Analysis for Economic Evaluations Alongside Clinical Trials--Extrapolation with Patient-Level Data: Inconsistencies, Limitations, and a Pract... 18 Jul 2013 | 12:06 am

Background. In health technology assessments (HTAs) of interventions that affect survival, it is essential to accurately estimate the survival benefit associated with the new treatment. Generally, tri...

An Efficient Method for Computing Single-Parameter Partial Expected Value of Perfect Information 18 Jul 2013 | 12:06 am

The value of learning an uncertain input in a decision model can be quantified by its partial expected value of perfect information (EVPI). This is commonly estimated via a 2-level nested Monte Carlo ...

A Mathematical Approach for Evaluating Markov Models in Continuous Time without Discrete-Event Simulation 18 Jul 2013 | 12:06 am

Markov models are a simple and powerful tool for analyzing the health and economic effects of health care interventions. These models are usually evaluated in discrete time using cohort analysis. The ...

Development of a Framework for Cohort Simulation in Cost-Effectiveness Analyses Using a Multistep Ordinary Differential Equation Solver Algorithm in R 18 Jul 2013 | 12:06 am

Introduction. Dynamic processes in cost-effectiveness analysis (CEA) are typically described using cohort simulations, which can be implemented as Markov models, or alternatively using systems of ordi...

US Valuation of the SF-6D 18 Jul 2013 | 12:06 am

Background. The original SF-6D valuation study collected 3503 standard gambled responses from 611 UK respondents to predict quality-adjusted life year (QALY) values. Methods. Using 19,980 paired compa...

Hospital Variation in Patient-Reported Outcomes at the Level of EQ-5D Dimensions: Evidence from England 18 Jul 2013 | 12:06 am

Background. The English Department of Health has introduced routine collection of patient-reported outcome data for selected surgical procedures to facilitate patient choice and increase hospital acco...

Patient and Societal Value Functions for the Testing Morbidities Index 18 Jul 2013 | 12:06 am

Background: We developed preference-based and summated scale scoring for the Testing Morbidities Index (TMI) classification, which addresses short-term effects on quality of life from diagnostic testi...

Common Scale Valuations across Different Preference-Based Measures: Estimation Using Rank Data 18 Jul 2013 | 12:06 am

Background. Different preference-based measures (PBMs) used to estimate quality-adjusted life years (QALYs) provide different utility values for the same patient. Differences are expected since values...

Expressing Death Risk as Condensed Life Experience and Death Intensity 18 Jul 2013 | 12:06 am

Some risk exposures, including many medical and surgical procedures, typically carry hazards of death that are difficult to convey and appreciate in absolute terms. I propose presenting the death risk...