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Elevated 18F-FDG Levels in Blood and Organs After Angiotensin II Receptor Blocker Administration: Experiment in Mice Administered Telmisartan 1 Aug 2013 | 06:01 pm
Angiotensin II receptor blockers (ARBs) are a common treatment for hypertensive patients but affect renal function. In this study, the effects of ARB on 18F-FDG distribution and excretion were examine...
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry 1 Aug 2013 | 06:01 pm
The specificity of antibodies have made immunoconjugates promising vectors for the delivery of radioisotopes to cancer cells; however, their long pharmacologic half-lives necessitate the use of radioi...
Whole-Body Imaging of High-Dose Ionizing Irradiation-Induced Tissue Injuries Using 99mTc-Duramycin 1 Aug 2013 | 06:01 pm
High-dose ionizing irradiation can cause extensive injuries in susceptible tissues. A noninvasive imaging technique that detects a surrogate marker of apoptosis may help characterize the dynamics of r...
The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Col... 1 Aug 2013 | 06:01 pm
The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribut...
In Vivo Kinetic and Steady-State Quantification of 18F-CPFPX Binding to Rat Cerebral A1 Adenosine Receptors: Validation by Displacement and Autoradiog... 1 Aug 2013 | 06:01 pm
In vivo imaging of the A1 adenosine receptor (A1AR) using 18F-8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (18F-CPFPX) and PET has become an important tool for studying physiologic and pathologic...
Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease 1 Aug 2013 | 06:01 pm
Neurofibrillary tangles in Alzheimer disease (AD) brains are composed of the microtubule-associated protein tau. Noninvasive monitoring of tau protein aggregates in the living brain will provide usefu...
5-HT2A Receptors in the Feline Brain: 123I-5-I-R91150 Kinetics and the Influence of Ketamine Measured with Micro-SPECT 1 Aug 2013 | 06:01 pm
Subanesthetic doses of ketamine can be used as a rapid-acting antidepressant in patients with treatment-resistant depression. Therefore, the brain kinetics of 123I-5-I-R91150 (4-amino-N-[1-[3-(4-fluor...
Longitudinal Amyloid Imaging in Mouse Brain with 11C-PIB: Comparison of APP23, Tg2576, and APPswe-PS1dE9 Mouse Models of Alzheimer Disease 1 Aug 2013 | 06:01 pm
Follow-up of β-amyloid (Aβ) deposition in transgenic mouse models of Alzheimer disease (AD) would be a valuable translational tool in the preclinical evaluation of potential antiamyloid therapies. Thi...
In Vivo Molecular Imaging of Atherosclerotic Lesions in ApoE-/- Mice Using VCAM-1-Specific, 99mTc-Labeled Peptidic Sequences 1 Aug 2013 | 06:01 pm
Vascular cell adhesion molecule 1 (VCAM-1) plays a major role in the chronic inflammatory processes involved in vulnerable atherosclerotic plaque development. We previously showed that the 99mTc-label...
Systemic Image-Guided Liver Cancer Radiovirotherapy Using Dendrimer-Coated Adenovirus Encoding the Sodium Iodide Symporter as Theranostic Gene 1 Aug 2013 | 06:01 pm
Currently, major limitations for the clinical application of adenovirus-mediated gene therapy are high prevalence of neutralizing antibodies, widespread expression of the coxsackie-adenovirus receptor...
