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塩野義製薬株式会社が化学構造検索システムをリプレース 6 Sep 2011 | 04:09 pm

パトコア株式会社(本社:東京都・江東区)は、塩野義製薬株式会社(本社:大阪・中央区)から、化学構造式検索エンジン「JChem Cartridge for ORACLE」の国内無制限ユーザーライセンスを受注致しました。 塩野義製薬は研究過程で発生する化学構造関連情報の管理を従来の検索エンジンよりJChem Cartridgeにリプレースし、より高速かつ安定的に大量のデータの管理を行うとともに、シス...

エーザイ株式会社のグローバル創薬インフラを受注 1 Aug 2011 | 01:00 pm

パトコア株式会社は、エーザイ株式会社(本社:東京・文京区)から、創薬研究の基幹情報を管理するためのソフトウェア「JChem Cartridge for ORACLE」のグローバルライセンスを受注致しました。 本システムはエーザイが世界に展開する研究開発拠点において、研究過程で創生された化学構造情報の管理に用いられます。 同時に以前より国内の研究拠点で利用されていた化学物質の法規制化合物チェック...

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ActiTarg Series - Targeted Libraries timtec.com 11 Jun 2010 | 05:20 am

Molecules in targeted libraries possess cumulative structural characteristics common to known Nuclear Receptors and GPCR Ligands, Ion Channel and Kinase Modulators, Protease and Serpins Inhibitors. Mo...

ActiTarg Series - Targeted Libraries timtec.net 11 Jun 2010 | 05:20 am

Molecules in targeted libraries possess cumulative structural characteristics common to known Nuclear Receptors and GPCR Ligands, Ion Channel and Kinase Modulators, Protease and Serpins Inhibitors. Mo...

Alternative Splicing of the TRPC3 Ion Channel Calmodulin/IP3 Receptor-Binding Domain in the Hindbrain Enhances Cation Flux neuro.cjb.net 16 Aug 2012 | 12:01 am

Canonical transient receptor potential (TRPC3) nonselective cation channels are effectors of G-protein-coupled receptors (GPCRs), activated via phospholipase C–diacylglycerol signaling. In cerebellar ...

Topography of Native SK Channels Revealed by Force Nanoscopy in Living Neurons neuro.cjb.net 16 Aug 2012 | 12:01 am

The spatial distribution of ion channels is an important determinant of neuronal excitability. However, there are currently no quantitative techniques to map endogenous ion channels with single-channe...

AAQ chemical can reportedly restore sight to blind mice techgeer.com 27 Jul 2012 | 04:24 am

AAQ is based on a photoswitch that binds to protein ion channels on the surface of retinal cells. The chemical is called AAQ and it works by making the blind cells in the retina sensitive to light. (m...

Proceedings of the National Academy of Sciences USA online: August 8, 2013 newswire.rockefeller.edu 9 Aug 2013 | 02:51 am

Proceedings of the National Academy of Sciences USA online: August 8, 2013 UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 ...

Water molecules control inactivation and recovery of potassium channels uchospitals.edu 29 Jul 2013 | 10:00 pm

Just 12 molecules of water cause the long post-activation recovery period required by potassium ion channels before they can function again.

Open and shut: a breakthrough discovery on the slow inactivating K+ channel gate isgtw.org 21 Aug 2013 | 04:04 pm

Ion channels regulate electrical currents, many of which are primary to the body’s biological processes. Like tiny faucets, these channels open and close in response to signals, but the ways in which ...

PhD in Biophysics, Department of Biochemistry & Biophysics, Stockholm University, Sweden jobcqr.com 27 Aug 2013 | 02:01 pm

Project title: Electrophysiology & Modeling of Ligand-gated Ion Channels Membrane proteins are critical for signaling and transport across membranes, but these processes cannot be accomplished with st...

Spike statistics and coding properties of phase models from ion channels to neural coding edoc.hu-berlin.de 27 Aug 2013 | 11:45 am

Ziel dieser Arbeit ist es eine Beziehung zwischen den biophysikalischen Eigenschaften der Nervenmembran, und den ausgeführten Berechnungen und Filtereigenschaften eines tonisch feuernden Neurons, unt...

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