Assessment of endothelial dysfunction by flow-mediated dilatation in men on long-term androgen deprivation therapy for prostate cancer 21 Aug 2013 | 09:00 pm

Androgen deprivation therapy (ADT) in men with prostate cancer has been linked to an increased incidence of cardiovascular events and mortality, but the underpinning mechanisms are unclear. Endothelia...

Sternohyoid and diaphragm muscle form and function during postnatal development in the rat 21 Aug 2013 | 09:00 pm

The striated muscles of breathing, including the thoracic pump and pharyngeal dilator muscles, play a critical role in maintaining respiratory homeostasis. Whilst postnatal maturation of the diaphragm...

Impairment of pancreatic {beta}-cell function by chronic intermittent hypoxia 21 Aug 2013 | 09:00 pm

Breathing disorders with recurrent apnoea produce periodic decreases in arterial blood O2, i.e. chronic intermittent hypoxia (CIH). Recurrent apnoea patients and CIH-exposed rodents exhibit several co...

Consecutive transcranial magnetic stimulation twitches reduce flow limitation during sleep in apnoeic patients 21 Aug 2013 | 09:00 pm

Transcranial magnetic stimulation (TMS)-induced twitches applied on isolated breaths briefly recruit upper airway dilator muscles and improve airflow and inspiratory volume without arousing apnoeic pa...

Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice 21 Aug 2013 | 09:00 pm

Abnormalities in mitochondrial content, morphology and function have been reported in several muscle-wasting conditions. We specifically explored whether experimental cancer-induced cachexia may alter...

Treatment of muscle mechanoreflex dysfunction in hypertension: effects of L-arginine dialysis in the nucleus tractus solitarii 21 Aug 2013 | 09:00 pm

The blood pressure response to exercise is exaggerated in hypertension. Recent evidence suggests that an overactive skeletal muscle mechanoreflex contributes significantly to this augmented circulator...

Cardiorespiratory coupling of sympathetic outflow in humans: a comparison of respiratory and cardiac modulation of sympathetic nerve activity to skin ... 21 Aug 2013 | 09:00 pm

It is well known that microelectrode recordings of skin sympathetic nerve activity (SSNA) in awake human subjects reveal spontaneous bursts of activity with no overt modulation by changes in blood pre...

Editorial Board 21 Aug 2013 | 09:00 pm

Physiology is rocking the foundations of evolutionary biology 20 Jul 2013 | 10:11 pm

The ‘Modern Synthesis' (Neo-Darwinism) is a mid-20th century gene-centric view of evolution, based on random mutations accumulating to produce gradual change through natural selection. Any role of phy...

Editorial Board 20 Jul 2013 | 10:11 pm